KP Phyto’s Newsletter

11 March 2024

NEWSLETTER

SHARING KNOWLEDGE & HELPING CUSTOMERS EXCEL

Vol 5/2024| Editor: Kerry Hughes, MSc.

Driving the global

supply chain in

Botanical Ingredients.

KP Phyto is positioned to

take on global supply chain

demands, and is the Indian

market leader catered to a

wide range of ingredients for

food, pharma, nutraceutical,

dietary supplements and

cosmetics.Thank you for your

interest in our newsletter &

allowing us to provide you

with deep dive perspectives

on Indian botanicals.

Newsletter Vol 5/2024

The Thunderbolt Botanical

Native to Africa and India, and introduced to many other

regions, Senna (Senna alexandrina; syn. Cassia acutifolia, C.

angustifolia, C. senna, C. lanceolata; Senna spp.) is a plant

from the pea (Fabaceae) family that grows about 1 meter

tall with yellow pea-like flowers in racemes, followed by flat

leguminous seed pods. At K. Patel, we are focused on

Cassia angustifolia.

Interestingly, Senna is one of the rare botanicals that have

been officially approved by the US FDA as an over-the-

counter drug (OTC).

It is approved for short-term use for adults and children 2

years and older as a digestive aid, intended for short-term

relief of constipation.

KP Phyto’s Newsletter

11 March 2024

Huge & Growing Market

Senna is among the most commonly prescribed medications

in the US, with more than 1 million prescriptions (the 291st

most common in 2020). Not only is it one of the most

commonly used botanicals in the world, with global leaf

extracts reaching over USD 29 Billion in 2023, but it is

predicted to grow at a CAGR of 10.2% through 2032,

according to an Expert Market Research (EMR) report. India

is the top exporter of Senna leaves in the world, with its top

markets being the US, China and Thailand. It may not be an

indication that many of us want to talk about, but

constipation is clearly one of the top afflictions in the world.

Traditional Medicine

Senna is present in traditional medicine systems around the

world for its laxative use and other indications, and both the

leaf and seed use is common. Senna is also marketed for

other uses as a Dietary Supplement, such as detoxification/

cleansing, weight management and digestive health. In

Traditional Chinese Medicine, Cassiae Semen is a

preparation from the seeds of C. obtusifolia or C. tora, which

has long been used as a laxative, for supporting blood sugar

balance, and eye and liver health.

In Ayurveda, Senna is referred to as Svarnapatri, and mainly

used for blood purification and for supporting skin health. It

is considered hot, dry in nature and pungent, balancing to

excess Pita. For constipation the leaf is used in the dried

form with hot water. For supporting skin health, a paste of

the leaf is applied with vinegar, and other preparations

depend on the indication.

In Ayurveda, a popular preparation called Kayam Churna is

used for constipation. It contains 50% senna leaves mixed

Newsletter Vol 5/2024

KP Phyto has invested heavily

in understanding the points

along the supply chain that

must be controlled for the

best quality outcomes in

Senna ingredient quality. We

also invest into the

understanding and

development of the research

behind Indian traditional

KP Phyto’s Newsletter

11 March 2024

with black salt, Ajwain (Carum capticum), Haritaki

(Terminalia chebula), Svarjiksara (alkali preparation),

Licorice, and Trivrit (Operculina turpethum).As Senna

sometimes causes abdominal pain due to cramping, the

licorice of this formula helps with its antispasmodic action.

Active Compounds

Senna contains glycoside compounds called sennosides,

which are irritant laxatives, and well characterized. It is

expected for a bowel movement to occur 6-12 hours after

use.Sennosides are high molecular weight dianthrone

glycosides, that are not absorbed by the GI tract, but rather

are hydrolyzed by enteric bacteria, causing an increase in

motility by stimulating the nerve plexus of the intestinal

smooth muscle.Senna is typically used at the level which

provides 17.2 mg sennosides, once or twice daily. The

maximum recommended dose is 34.4. mg sennosides,

twice daily.

Science & The Future

A number of studies have shown relief of constipation in

the short-term. There is also some evidence that taking it

with Psyllium can be more effective than Psyllium alone,

and produce more stool moisture when in combination.

Other uses for Senna are being investigated scientifically

and clinically. For example, in recent scientific investigation,

Senna has shown potential for supporting blood sugar

balance through a molecular docking study. As there are

traditional uses for blood purification and detoxification,

there is also some scientific confirmation on these uses

through liver support.

Newsletter Vol 5/2024

KP Phyto’s Newsletter

11 March 2024

Topical uses have also been emerging and/or being

confirmed through science. For example, Senna is being

investigated for antiaging, wound healing and burn care.In

one high tech study, C. angustifolia extract primed adipose-

derived stem cells were investigated for applications

regarding burn care with positive results.

Senna best grows in sandy soils, representing one of the

most important crops worldwide for dry land farming. As it

belongs to the Legume family, it is also able to fix nitrogen

and improve soil. In the sandy soils Senna also provides the

important function of soil conservation, as it helps hold the

sand particles together, reducing erosion potential, and

increasing soil fertility.

As Senna’s leaves and pod extracts are mostly exported, have

growing demand and are able to grow in arid lands that

otherwise are limited in productivity, they represent an

opportunity for both farmers and industry as the use and

demand continues to grow.

Newsletter Vol 5/2024

..more information

on calcium sennoside-senna &

other ingredients.

Visit:

https://phytoextractskp.com/

calcium-sennoside-senna-

extracts-manufacturers-suppliers/

or mail us at.

E:Info@phytoextractskp.com

K Patel Phyto-Achievement

in Innovation-2024

Our Branded Ingredient

Curcuvail won "Best Product

in the Innovation Zone

'Award-at VITAFOODS

-INDIA-2024

KP Phyto’s Newsletter

11 March 2024

Extractions Pvt Ltd(India)

Notice:-

This content is for

informational and educational

purposes only. It is not

intended to provide medical

advice or to take the place of

such advice or treatment from

a personal physician.

Kerry Hughes, MSc., The Ethnobotanical Explorer,

Kerry Hughes, MSc.,The Ethnobotanical Explorer & principal

for EthnoPharm, is an Ethnobotanist and Registered

Herbalist, with a 20-year record of success in natural product

development. EthnoPharm specializes in innovative product

formulation, education, and nexus-of-market opportunity

identification.

Newsletter Vol 5/2024