KP Phyto’s Newsletter
22July 2024
NEWSLETTER
SHARING KNOWLEDGE & HELPING CUSTOMERS EXCEL
Vol 9/2024| Editor: Kerry Hughes, MSc.
Driving the global
supply chain in
Botanical Ingredients.
KP Phyto is positioned to
take on global supply chain
demands, and is the Indian
market leader catered to a
wide range of ingredients for
food, pharma, nutraceutical,
dietary supplements and
cosmetics.Thank you for your
interest in our newsletter &
allowing us to provide you
with deep dive perspectives
on Indian botanicals.
Newsletter Vol 9/2024
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KP Phyto’s Newsletter
22July 2024
The berries of Tree Turmeric are often consumed, and roots
sometimes employed for making an alcoholic drink. The
whole plant is also used as a natural dye or for tanning
leather. A key bioactive compound in Tree Turmeric is
berberine, known for its wide-range of applications,
including blood sugar balance, as an antimicrobial and for
cardiovascular health. This is the source for KP Phyto
Berberine, which we carefully control for quality.
In Ayurveda, Tree Turmeric has a long traditional use, and its
stems and fruits are used for a wide range of indications,
particularly for helping to balance the Kapha and Pitta
Doshas.Various preparations are available. For example, a
decoction is often used as a wash. Another preparation is the
powder in a paste form with rose water and honey applied
topically for skin health. It is often used in blood sugar
balance, skin, liver, digestive, and eye health, and digestive
issues.
Huge & Growing Market
The Berberine market has strong growth, with an overall
global value of USD$ 1670.6 Mn in 2023, forecasted to reach
USD$ 4216.3 Mn by 2033, with a CAGR of 9.7% in this
period. The main benefits targeted by market are blood
sugar balance, heart health and gastrointestinal wellness.
Pharmacology
Through scientific investigation Berberine has been found to
have a wide range of activities, including antimicrobial,
antioxidant, cytokine and blood sugar
balancing,Hepatoprotective, cardioprotective, and
neuroprotective.
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KP Phyto’s Newsletter
22July 2024
Among the wide range of uses of Berberine, currently it has
gained the most amount of attention for its use in balancing
blood sugar.
Blood Sugar Balance
Among the wide range of uses of Berberine, currently it has
gained the most amount of attention for its use in balancing
blood sugar. Several possible mechanisms of action have
been found which may contribute to its use in blood sugar
balance. One of the mechanisms found in preclinical
research is the increasing of glucagon-like peptide (GLP-1)
secretion, which plays a role in the maintenance of blood
sugar control. However, Berberine’s effect on GLP-1 has not
been shown in randomized clinical studies to have this effect,
which is an area being touted for Berberine in social media.
There are several other possible mechanisms for Berberine’s
use in blood sugar balance.One is its ability to increase
insulin receptor expression in peripheral blood lymphocytes.
Another, its ability to increase AMP-activated protein kinase
(AMPK) activity, which may stimulate glucose uptake in the
skeletal muscle.Lastly, it has been shown to increase
peroxisome proliferator-activated receptor (PPAR)-alpha and
PPAR-delta expression.The potential effect of inhibiting
aldose reductase may also help protect the nerves and eyes
in states of out of balance blood sugar.
Blood Lipids and Cytokine Balance
Several meta-analyses of clinical studies have found
Berberine to cause a reduction of C-reactive protein (CRP).
Additionally, it has been found to reduce tumor necrosis
factor (TNF)-alpha and interleukin-6 (IL-6) in clinical studies.
In preclinical research, it has also shown effects on cytokine
balance of several cytokines, including blocking production
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KP Phyto’s Newsletter
22July 2024
of interleukin-1 (IL1)-beta and tumor necrosis factor (TNF)-
alpha. Early research has found it may also inhibit
cyclooxygenase (COX)-2 expression.
Berberine has been found in several clinical studies to
promote healthy blood lipid profiles.One possible
mechanism is through inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9); it may effect the uptake of
low-density lipoprotein particles by the liver. Other
mechanisms have been found preclinically which may explain
its beneficial effects on blood lipid profiles. These include its
effects on increasing bile acid synthesis, or by promoting
AMP-activated protein kinase (AMPK) in the liver and
muscles.
Other Beneficial Mechanisms
Several other beneficial mechanisms have been found
through research that may result in benefits to a wide range
of health outcomes. For example, Berberine has been found
to exhibit antioxidant effects through the increase of activity
of superoxide dismutase, and reduction of malondialdehyde
and superoxide anion. It also has been found to inhibit
platelet aggregation, possibly through the inhibition of the
synthesis of thromboxane A2.Berberine has also been shown
to have muscle relaxant effects , possibly through the
inhibition of acetylcholine-included contraction of smooth
muscles, as well as gastroprotective effects through the
reduction of gastric acid secretion.
Newsletter Vol 9/2024
To le a r n m o r e ab o ut th e
latest updates on botanical
ingredients .
Visit Us:
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4
Science & The Future
Several areas of research are emerging for the usefulness of
Berberine, including its effect on promoting mitochondrial
health. A key characteristic that stands out with Berberine is
its multi-faceted effects on physiology, with clinical studies
showing positive benefits in widespread areas of health and
KP Phyto’s Newsletter
22July 2024
For example, a study published in 2022 explored the
potential of Berberine in promoting healthy blood sugar
balance, cardiovascular health and blood lipid profiles. This
randomized controlled trial, involving 200 participants,
found Berberine significantly improved insulin sensitivity and
lowered fasting blood glucose levels when compared to a
placebo group.Participants who received berberine also
showed marked reductions in HbA1c levels, indicating better
long-term glucose control. Moreover, the study highlighted
Berberine's ability to promote healthy lipid profiles, thus
offering a comprehensive approach to managing multiple
aspects of aging and western living. The findings underscore
the multi-faceted potential of Berberine.
One confounding issue with Berberine has been its low
absorption. However, several studies have shown that
Berberine exerts a local effect on the microbiome. With this
evidence, I think it is likely, also with the range of the main
types of benefits observed with Berberine, that we will find
that Berberine’s benefits on health start in the upstream
physiological processes that have to do with digestion,
absorption, blood sugar balance, and then extending to the
resulting cascades of hormones and cytokines involved with
downstream health outcomes.
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© K Patel Phyto
Extractions Pvt Ltd(India)
Notice:-
This content is for
informational and educational
purposes only. It is not
intended to provide medical
advice or to take the place of
such advice or treatment from
a personal physician.
KP Phyto’s Newsletter
22July 2024
Newsletter Vol 9/2024
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Kerry Hughes, MSc,The Ethnobotanical Explorer,
Kerry Hughes, MSc.,The Ethnobotanical Explorer & principal
for EthnoPharm, is an Ethnobotanist and Registered
Herbalist, with a 20-year record of success in natural product
development. EthnoPharm specializes in innovative product
formulation, education, and nexus-of-market opportunity
identification.