KP Phyto’s Newsletter
18 Aug 2024
NEWSLETTER
SHARING KNOWLEDGE & HELPING CUSTOMERS EXCEL
Vol 10/2024| Editor: Kerry Hughes, MSc.
Driving the global
supply chain in
Botanical Ingredients.
KP Phyto is positioned to
take on global supply chain
demands, and is the Indian
market leader catered to a
wide range of ingredients for
food, pharma, nutraceutical,
dietary supplements and
cosmetics.Thank you for your
interest in our newsletter &
allowing us to provide you
with deep dive perspectives
on Indian botanicals.
Newsletter Vol 10/2024
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Squarely Medicinal
This creeping vine has a form so distinctive, it is easy to
identify once you see it! Cissus (aka. Veldt Grape, Bone
Setter, Hadjod; Cissus quadrangularis) is a perennial plant in
the grape family distinguished by quadrangular (four-angled)
stems.
Cissus’ stems are thick and fleshy and often favored as an
ornamental plant, with multiple other uses, including as a
medicinal plant. Native to Africa, parts of Asia and India,
Cissus thrives in tropical and subtropical climates.
Multiple Uses Beyond Traditional Medicine
Various parts of Cissus have uses: its stems and leaves are
used as vegetables in culinary applications; the plant's sap is
employed as a natural dye; its strong, fibrous stems are
sometimes used in making ropes and baskets; and it has
long been used in traditional medicine.especially in
KP Phyto’s Newsletter
18 Aug 2024
Ayurveda and Siddha. Additionally, there is interest in
research for applications in the pharmaceutical industry due
to its medicinal properties.
Traditional Medicinal Use
Cissus has uses in several traditional medicine systems, and
overall it’s main uses are for promoting bone and digestive
health. It is also used to promote blood sugar balance,
healthy weight, for its calming properties, and as an
aphrodisiac.
In Ayurveda, Cissus is renowned for its use in promoting
bone health, often used for accelerating the healing
process. It is considered pacifying to the Vata and Kapha
doshas, making it particularly useful for promoting bone
health with its grounding, nourishing and slightly heating
properties.
In Siddha, Thai, Unani and other Southeast Asian regions its
uses are similar to Ayurveda in promoting bone health, with
additional uses in promoting joint, respiratory and menstrual
health. In Africa, beyond bone health it is also known as a
general tonic to strengthen the body and promote
immunity.
Huge & Growing Market
Cissus quadrangularis is experiencing a growing market,
driven by its increasing popularity as a dietary supplement.
The global market for Cissus quadrangularis is seeing
expansion across multiple regions, including North America,
Europe, Asia-Pacific, Latin America, and the Middle East and
Africa. The aging population's demand for supplements that
support bone health and joint mobility is a driving factor in
its market growth.
Newsletter Vol 10/2024
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KP Phyto has invested heavily in
understanding the points along
the supply chain that must be
controlled for the best quality
outcomes in Cissus ingredient
quality. We also invest into the
understanding and
development of the research
behind Indian traditional
botanicals…with a focus this
month on Cissus.
KP Phyto’s Newsletter
18 Aug 2024
Pharmacology
Through scientific investigation Cissus has been found to
exhibit various activities, including antioxidant,
antispasmodic, cytokine & blood sugar balancing,
gastroprotective, promoting comfort, gastrointestinal, liver
and bone health.
Cissus contains a number of bioactive compounds,
including flavonoids, ketosteroids, triterpenes, quercetin,
various polyphenols and stilbenes (such as pallidol,
resveratrol, quadrangularin A, piceatannol and
perthenocissin). Also present are vitamins and minerals,
such as Vitamin C & E, carotenoids, and calcium.
Several activities have been observed in preclinical studies,
which may be explained as mechanisms of action for its
role in promoting bone health. It has been observed to
stimulate bone growth and thickness, as well as osteoblast
proliferation, differentiation and mineralization.
Additionally, it has been found to decrease osteoclast
activity. In osteoplasts, it has been observed to increase
mRNA and protein expression of the Runt-related
transcription factor-2, a factor involved in bone
development. It is thought that the osteogenic activity of
Cissus is moderated by a MAPK-dependent mechanism.
Gastrointestinal effects have also been observed in
preclinical studies, confirming some of its traditional uses.
For example, antioxidant effects, such as glutathione, have
been observed which may be an underlying mechanism for
its gastroprotective effects. It has also been observed to
stimulate gastric cell proliferation and increase the
secretion of gastric mucus.
Newsletter Vol 10/2024
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KP Phyto’s Newsletter
18 Aug 2024
In weight management, it is postulated that since its
constituents have been observed to inhibit lipase and
amylase, it may reduce the absorption of dietary fats and
carbohydrates. There may also be effects on promoting
satiety, as an increase of serotonin and creatinine levels have
been observed.
Science & The Future
There have been several small clinical studies into the
various applications for Cissus. As the preclinical work has
been progressing into understanding what mechanisms may
be at work, it is also exciting that several small clinical
studies have shown benefit in humans. Yet, the best clinical
substantiation behind Cissus’ traditional uses so far is for
supporting a healthy weight. Beyond weight management,
Cissus was found in a few of these studies to have positive
effects on blood lipid chemistry and metabolism.
Positive benefits have been observed in clinical studies in
humans on other areas of health, including its
gastroprotective and liver protective effects, cytokine
balance, comfort, and antioxidant activities.
As Cissus has traditional uses and preclinical confirmation
into its use in gut health, it is likely this will be an area of
strong growth in the future for Cissus as the science
progresses. As our understanding on how integral the gut is
to overall health, it is my prediction that beyond bone
health, Cissus will be sought after in formulations due to its
gastrointestinal effects, especially its due to its protective
role on the gastric mucosa.
Newsletter Vol 10/2024
..more information
on Cissus quadrangularis &
other ingredients.
Visit:
https://phytoextractskp.com/
herbal-extracts-manufacturers-
suppliers/
or mail us at.
E:Info@phytoextractskp.com
4
Meet us at CPHI-
Korea -2024
We are delighted to invite you
to visit our booth, B33, at CPHI
Korea, taking place in Seoul
from August 27th to 29th,
2024.Discover the ultimate
source of authentic botanical
extracts and experience
firsthand quality and innovation
that set us apart in the industry.
KP Phyto’s Newsletter
18 Aug 2024
© K Patel Phyto
Extractions Pvt Ltd(India)
Notice:-
This content is for
informational and educational
purposes only. It is not
intended to provide medical
advice or to take the place of
such advice or treatment from
a personal physician.
Kerry Hughes, MSc., The Ethnobotanical Explorer,
Kerry Hughes, MSc.,The Ethnobotanical Explorer & principal
for EthnoPharm, is an Ethnobotanist and Registered
Herbalist, with a 20-year record of success in natural product
development. EthnoPharm specializes in innovative product
formulation, education, and nexus-of-market opportunity
identification.
Newsletter Vol 10/2024
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