Introducing inventive Curcumin formula for advanced Bioavailability!!
What is Turmeric?
Turmeric (Curcuma longa, an Indian spice), a herbaceous plant of ginger family, Zingiberaceae, the roots of which has traditionally been used in cooking. Turmeric is a plant that has a very long history of medicinal use, dating back nearly 5000 years where Indian Ayurvedic science recognised it. In Southeast Asia, turmeric is used not only as a principal spice but also as a component in religious ceremonies. Because of its brilliant yellow color, turmeric is also known as “Indian saffron.” Of late, modern nutritional and medicine science has begun to recognise its value and importance. This is indicated by the presence of over 6000+ papers and publications in just last three decades. India grows world’s 85% Turmeric roots of high quality. The bioactive constituents of Turmeric are curcumin, demethoxycurcumin, bis-demethoxycurcumin and more than 30 essential oils.
What is Curcumin?
Commercially Curcuminoids are known as Curcumin which contains three polyphenols namely, curcumin, demethoxycurcumin, and bis-demethoxycurcumin. Curcumin has diverse therapeutic/pharmacological actions with well-documented pharmacokinetics, efficacy & safety.
Mechanism, how it works?
It has interactions with numerous targets, inhibiting activation of transcription factors, downregulation of the activity of multiple kinases, inhibits expression of growth and metastasis promoting genes, cell invasion, and adhesion, regulates activities of several enzymes that mediate tumor growth and so on. Curcumin regulates the expression of inflammatory enzymes, cytokines, adhesion molecules, and cell survival proteins.
Various studies have shown that Curcumin helps in Joint & muscles health, Boosts cognitive function, Fights inflammation, Boosts detoxification, Support cardiovascular function, and Promotes healthy mood balance.
What is CurcuVail®
CurcuVail® is a unique innovative Curcumin that is specially designed using dispersion technology. It has evolved and extended traditional goodness of Curcumin by enhancing its bioavailability.
Conventional Curcumin owing to its poor bioavailability leads to lower efficacy in any application made from it. A highly bioavailable and better water-dispersible substance helps quicker absorption in human body. The enhanced bioavailable CurcuVail helps design and configures applications that increase its absorption into human body leading to faster end effect.
Salient features of CurcuVail®
- No Residual solvent.
- No Pesticides residue
- No Odor and Taste of turmeric
- Completely water dispersible
- Easy to clean the equipment after process
- No bioavailability enhancer required
- Non GMO
- Self affirmed GRAS
- User friendly for all applications like Beverage, Food, Confectionaries, Nutraceuticals, Premix, Cosmetics etc.
Higher dispersion attribute will help beverage absorb CurcuVail® more homogeneously into water. This will give beverage a better color and taste that does not interfere with the original product flavor.
Confectionery and baked products are exposed to a higher temperature in their cooking process. CurcuVail® remains stable with higher heat exposure and retains the product’s taste properties.
Use of CurcuVail® will help your end product for appropriate end effective brand communication supported by the above values. There are clinical studies to support the same for authenticity and accuracy.
Use of CurcuVail® helps to reduce dosage as the higher bioavailability increases efficacy of formulation. This makes the formulation smarter and effective.
CurcuVail® acts as a natural colorant with its nutritional values intact. It does not interfere with the original taste of the food product.
CurcuVail® as an ingredient perfectly blends with any medium as nutrient and absorbs into the water seamlessly. This gives a premix an ideal palatable blend and taste.
Objective: To compare bioavailability of CurcuVail® with Curcumin 95%.
Number of subjects: 24 (two groups of 12 each)
An open-label, balanced, randomized, crossover, relative, bioavailability study of Turmeric Extract two-treatment, two-period, two-sequence, single-dose, (Curcumin) 500mg capsule with Turmeric bio-available extract 500mg capsule of CurcuVail® , in healthy 24 adults human subjects under fasting conditions.
Results: Mean Plasma concentration (ng/ml) Vs Time (h) of Curcumin.
Cmax: CurcuVail® showed a significantly higher concentration of Curcumin in blood plasma compared to Curcumin 95%. The mean concentration of Curcumin was found to be 82ng/ml for CurcuVail® compared to 36ng/ml for Curcumin 95% at Tmax of around 5 hours.
Conclusion: CurcuVail® has substantially significant absorption of Curcumin in the blood as compared to Curcumin 95%. This study shows that CurcuVail® is more than 3X times absorbed in the blood or 9X more bioavailable when compared with Curcumin at same concentration. .
Chronic Bronchitis Study
“A Prospective, Interventional, Randomized, Parallel, Double blind, Placebo Controlled Clinical Study to evaluate the Efficacy & Safety of Curcumin capsule (CurcuVail®) in Patients with cough due to Chronic Bronchitis.”
Objective: To assess the efficacy of Curcumin capsule (CurcuVail®) in Patients with cough due to Chronic Bronchitis.
Dose: 500mg twice a day
Duration: 10 weeks
Number of subjects: 40
At End of Treatment, CurcuVail® statistically showed significant improvement in symptoms of chronic bronchitis such as Coughing, Mucus secretion, Wheezing in lungs, Low grade fever, Chest discomfort, Shortness of breath, Cold and Recurrence of respiratory infection.
Chest X-ray analysis revealed significant improvement in mucus clearance of bronchi. Immunological parameters such as total IgG, IgM and IgE level were also markedly improved in comparison to Placebo group.
Conclusion: The study concludes that CurcuVail® (Special Curcumin) owing to its anti-inflammatory and immuno-modulatory effect, was not only safe but also significantly efficacious in treatment of all major symptoms of Chronic bronchitis. This study has also proven potential of Curcuvail as marked immunity enhancer.
Joint Pain Study
A Prospective, Interventional, Randomized, Parallel, Double blind, Placebo Controlled Clinical Study to evaluate the Efficacy & Safety of Curcumin capsule (Analytical Specification Of CurcuVail®) in Patients with Chronic joint pain (Rheumatoid Arthritis).
Objective: To show the efficacy of CurcuVail® in Patients with Chronic joint pain (Rheumatoid Arthritis).
Dose: 500mg twice a day
Duration: 12 weeks
Number of subjects: 30
At the end of the study, statistical analysis of efficacy using CGI (Clinical Global Impression) scale and Global improvement Score, suggested that the patient group treated with CurcuVail® showed marked improvement in overall therapeutic effect as compared to Placebo group.
X-ray analysis of Knee joint PA has revealed that the CurcuVail® exhibited remission of inflammatory anomalies of joint in all patients which proved anti-inflammatory potential of Curcuvail as compared to Placebo group.
Anti-CCP (anti-cyclic citrullinated peptide) analysis in blood showed significant correction in this RA specific marker in the patients who received CurcuVail® treatment. This result indicated certain efficacy of CurcuVail® on immunity markers and so
as in reversal of arthritic changes.
Conclusion: The study concludes that, TEST (CURCUMIN) due to its anti-inflammatory and immunomodulatory effect it is more efficacious and safer in comparison to PLACEBO (B) in treatment of chronic joint pain due to Rheumatoid Arthritis.
Analytical Specification Of CurcuVail®
|PLANT PART USED|
|DOC.NO & REV.NO.|
|QC/CS/1002 & 05|
|QC/CS/1002 & 08.02.2019|
|21 – 32 :1|
|COUNTRY OF ORIGIN|
|GMO & IRRADIATION STATUS|
|Non GMO & Non Irradiated|
|Scientific name of ingredient is Curcuma longa|
Moisture content (By KF)
Yellow Orange coloured powder having characteristic odour.
Dispersable in water
Positive for Curcuminoids
Not more than 8.00
Between 4.0 – 8.0
Not more than 5.0
Not more than 2.0
Not more than 0.3
Not more than 0.1
ICP – MS
ICP – MS
ICP – MS
ICP – MS
Curcuminoids content (by HPLC)
Not less than 35.00
Total plate count
Yeast & mold count
Not more than 3000
Not more than 100
Absent / 10 gm
Absent / 25 gm
Absent / 10 gm
Grade: Food and Pharma
Purpose: Food and Food Supplement
Shelf life: 2 years from the month of manufacture
Standard Packaging details :
Net 20 / 25 kg product in double lined polybag, sealed with tie lock sequentially. The sealed bags are kept in
HDPE drums with silica gel placed on the bags and covered by HDPE lid, clamped and locked with Plastic tamper
seal lock .
Storage: Store in dry & tight containers
Remarks: Since the product is derived from natural origin there is possibility of marginal dissimilarity in colour
o wing to variations in ecological, climatic and source of raw material.