Tinospora cordifolia popularly known as “Guduchi” and “Giloy” has numerous applications in the traditional Ayurvedic literature. It belongs to the plant family Menispermaceae and is large, deciduous climbing shrub with greenish yellow typical flowers, found at higher altitude. The stem has diverse medicinal properties like anti- oxidant, anti-inflammatory, anti-tuberculosis; wound healing, immunomodulatory and immunoprotective, hepato-protectant, anti-osteoporotic, anti-cancer, anti-tumour, and anti-malaria.
is a Trademarked Branded Ingredient of K. Patel Phyto Extractions Pvt. Ltd. It is standardised extract of Tinospora cordifolia, standardised to Total Alkaloids and Total Terpenoids content. The manufacturing process has been developed in-house with the solvents which meet regulatory standards worldwide.
The pre-clinical study of is complete and the human clinical study is ongoing. Various parameters were taken into account like – spleen and thymus index, macrophage phagocytic index and macrophage phagocytic rate, Neutrophil adhesion. In the pre-clinical trials, treatment with prevented cyclophosphamide induced increased Cytokine response and restored Cytokines levels.
In the pre-clinical study, Serum levels of inflammatory cytokines, TNF-α, were decreased significantly (p<0.05) when compared to normal control group. After treatment with , there was significant (p<0.001) increase in serum levels of TNF-α when compared to disease control group.
Tinospora was found promising as an immunity enhancer since it has significantly restored cyclophosphamide induced immune-suppression, increased humoral immunity and improved phagocytic cell activity.
Effect of treatment with Tinospora on serum TNF-α levels
Each bar represents Mean + S.E.M, * – significantly different from normal control (p <0.05), $- significantly different from disease control (p<0.001)Spleen and thymus indices in disease control group were significantly (p<0.001) decreased when compared with normal control group. After treatment with Tinofolia spleen and thymus indices were increased significantly (p<0.001) when compared with disease control group
Effect of Treatment with Tinospora on Spleen Index
Each bar represents Mean +S.E.M,@ – significantly different from normal control (p <0.001), $- significantly different from disease control (p<0.001)
NC = Normal Control, DC = Disease Control, DC+T = Disease Control with treatment
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K. Patel Phyto Extractions Pvt. Ltd. Works on 360° Supply Chain Management. It sources raw material from its contractual farms and have identified the regions for its focused herbs and hence offering complete traceability from farm to extracts. It promotes pesticides free farming, educates farmers on Organic methods of cultivation and practice Good Agricultural Practices (GAP).
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